PIK3CA Clear Cell Carcinoma of the Ovary

Clear cell carcinoma of the ovary is a rare and highly lethal subtype of ovarian carcinoma due to its chemoresistant nature. Interestingly, clear cell carcinoma of the ovary also has a high frequency of activating mutations in the PIK3CA gene. Dr. Dejan Juric, MD is recognized as an expert in PIK3CA, having helped developed the first gene-targeted treatment for women with HR+ breast cancer with the PIK3CA gene mutation. Dr. Juric would now like to investigate whether PIK3CA is a valid target for other cancers, such as clear cell carcinoma of the ovary.